Issue 41, 2015
From the journal:

Chemical Communications

A platinum prodrug conjugated with a photosensitizer with aggregation-induced emission (AIE) characteristics for drug activation monitoring and combinatorial photodynamic–chemotherapy against cisplatin resistant cancer cells†

Youyong Yuan,‡a   Chong-Jing Zhang‡a  and  Bin Liu*ab  

* Corresponding authors

a Department of Chemical and Biomolecular Engineering, National University of Singapore, 4 Engineering Drive 4, Singapore
E-mail: cheliub@nus.edu.sg

b Institute of Materials Research and Engineering, Agency for Science, Technology and Research (A*STAR), 3 Research Link, Singapore

Abstract

A targeted and image-guided platinum prodrug conjugated with a photosensitizer with aggregation-induced emission (AIE) characteristics was designed for real-time and in situ drug activation monitoring in cancer cells as well as combinational photodynamic–chemotherapy against cisplatin resistant cancer cells.

Graphical abstract: A platinum prodrug conjugated with a photosensitizer with aggregation-induced emission (AIE) characteristics for drug activation monitoring and combinatorial photodynamic–chemotherapy against cisplatin resistant cancer cells

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Article information

DOI
https://doi.org/10.1039/C5CC01952D
Article type
Communication
Submitted
08 Mar 2015
Accepted
14 Apr 2015
First published
15 Apr 2015

Chem. Commun., 2015,51, 8626-8629

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A platinum prodrug conjugated with a photosensitizer with aggregation-induced emission (AIE) characteristics for drug activation monitoring and combinatorial photodynamic–chemotherapy against cisplatin resistant cancer cells

Y. Yuan, C. Zhang and B. Liu, Chem. Commun., 2015, 51, 8626 DOI: 10.1039/C5CC01952D

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