Issue 42, 2015
From the journal:

Chemical Communications

Kinamycin biosynthesis employs a conserved pair of oxidases for B-ring contraction†

Bin Wang,‡ab   Jinwei Ren,‡c   Liyuan Li,a   Fang Guo,ab   Guohui Pan,ab   Guomin Ai,a   Bertrand Aigle,de   Keqiang Fan*a  and  Keqian Yang*a  

* Corresponding authors

a State Key Laboratory of Microbial Resources, Institute of Microbiology, Chinese Academy of Sciences, 100101 Beijing, China
E-mail: fankq@im.ac.cn, yangkq@im.ac.cn

b University of Chinese Academy of Sciences, 100049 Beijing, China

c State Key Laboratory of Mycology, Institute of Microbiology, Chinese Academy of Sciences, 100101 Beijing, China

d Université de Lorraine, Dynamique des Génomes et Adaptation Microbienne, UMR 1128, Vandœuvre-lès-Nancy, France

e INRA, Dynamique des Génomes et Adaptation Microbienne, UMR 1128, Vandœuvre-lès-Nancy, France

Abstract

The biosynthesis of diazobenzofluorene kinamycins requires a hitherto uncharacterized B-ring contraction. Via detailed genetic and enzymatic analyses we unambiguously characterized the conserved pairs of oxidases, AlpJ and AlpK homologs, as nature's machinery for benzofluorenone formation, which paves the way for the investigation of the following diazo assembly.

Graphical abstract: Kinamycin biosynthesis employs a conserved pair of oxidases for B-ring contraction

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Article information

DOI
https://doi.org/10.1039/C5CC01986A
Article type
Communication
Submitted
09 Mar 2015
Accepted
08 Apr 2015
First published
08 Apr 2015

Chem. Commun., 2015,51, 8845-8848

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Kinamycin biosynthesis employs a conserved pair of oxidases for B-ring contraction

B. Wang, J. Ren, L. Li, F. Guo, G. Pan, G. Ai, B. Aigle, K. Fan and K. Yang, Chem. Commun., 2015, 51, 8845 DOI: 10.1039/C5CC01986A

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