Issue 43, 2015
From the journal:

Chemical Communications

Multivalent aptamer–RNA based fluorescent probes for carrier-free detection of cellular microRNA-34a in mucin1-expressing cancer cells†

Jihyun Kim,a   Eunjoo Lee,a   Yoon Young Kanga  and  Hyejung Mok*a  

* Corresponding authors

a Department of Bioscience and Biotechnology, Konkuk University, 120 Neungdong-ro, Gwangjin-gu, Seoul 143-701, Republic of Korea
E-mail: hjmok@konkuk.ac.kr
Tel: +82-2-450-0448

Abstract

In this study, multivalent carrier-free aptamer–RNA based fluorescent probes (CF-probes) were designed as a simpler, more reliable, timesaving strategy for cellular miRNA detection. CF-probes spontaneously delivered into cells without the need for additional carriers and visualized target microRNA-34a specifically.

Graphical abstract: Multivalent aptamer–RNA based fluorescent probes for carrier-free detection of cellular microRNA-34a in mucin1-expressing cancer cells

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Article information

DOI
https://doi.org/10.1039/C5CC02052B
Article type
Communication
Submitted
10 Mar 2015
Accepted
24 Apr 2015
First published
24 Apr 2015

Chem. Commun., 2015,51, 9038-9041

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Multivalent aptamer–RNA based fluorescent probes for carrier-free detection of cellular microRNA-34a in mucin1-expressing cancer cells

J. Kim, E. Lee, Y. Y. Kang and H. Mok, Chem. Commun., 2015, 51, 9038 DOI: 10.1039/C5CC02052B

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