A novel chemical methodology is described for the conversion of [11C]CO2 to [11C]CO. Diphenylmethyl silanes trap [11C]CO2 and release [11C]CO rapidly when triggered by TBAF. Released [11C]CO was used to produce [11C]N-benzylbenzamide and AMPA receptor ligand, [11C]CX546, in radiochemical yields >90% within 6 min from [11C]CO2 production.
![Graphical abstract: [11C]CO2 to [11C]CO conversion mediated by [11C]silanes: a novel route for [11C]carbonylation reactions](/en/Image/Get?imageInfo.ImageType=GA&imageInfo.ImageIdentifier.ManuscriptID=C5CC02095F&imageInfo.ImageIdentifier.Year=2015)
C. Taddei, S. Bongarzone, A. K. Haji Dheere and A. D. Gee, Chem. Commun., 2015, 51, 11795 DOI: 10.1039/C5CC02095F
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