Magnetic metal–organic framework nanocomposites for enrichment and direct detection of small molecules by negative-ion matrix-assisted laser desorption/ionization time-of-flight mass spectrometry†
Abstract
Zeolitic imidazolate framework-8 coated magnetic nanocomposites (Fe3O4@ZIF-8 MNCs) served as an absorbent and a matrix for negative-ion MALDI-TOF MS. The host–guest property and interference-free background made them an ideal dual platform for the sensitive analysis of small molecules.