Enabling [18F]-bicyclo[6.1.0]nonyne for oligonucleotide conjugation for positron emission tomography applications: [18F]-anti-microRNA-21 as an example

Xiang-Guo Li; Anne Roivainen; Jörgen Bergman; Arttu Heinonen; Frank Bengel; Thomas Thum; Juhani Knuuti

doi:10.1039/C5CC02618K

You do not have JavaScript enabled. Please enable JavaScript to access the full features of the site or access our non-JavaScript page.

Enabling [¹⁸F]-bicyclo[6.1.0]nonyne for oligonucleotide conjugation for positron emission tomography applications: [¹⁸F]-anti-microRNA-21 as an example†

Xiang-Guo Li,

*^ab Anne Roivainen,^ac Jörgen Bergman,^ab Arttu Heinonen,^d Frank Bengel,^e Thomas Thum^f and Juhani Knuuti^a

Author affiliations

* Corresponding authors

^a Turku PET Centre, University of Turku and Turku University Hospital, FI-20521 Turku, Finland
E-mail: xiali@utu.fi

^b Accelerator Laboratory, Åbo Akademi University, Porthansgatan 3, FI 20500 Turku, Finland

^c Turku Center for Disease Modeling, University of Turku, FI-20014 Turku, Finland

^d Proteomics Facility, Turku Centre for Biotechnology, FI-20014 Turku, Finland

^e Department of Nuclear Medicine, Hannover Medical School, Hannover, Germany

^f Institute of Molecular and Translational Therapeutic Strategies (IMTTS), Hannover Medical School, Hannover, Germany

Abstract

A bicyclononyne-based prosthetic group has been developed for ¹⁸F-labeling of anti-microRNA-21, an oligonucleotide, in a near-stoichiometric manner.

Download options Please wait...

Supplementary files

Supplementary information PDF (1436K)

Article information

DOI: https://doi.org/10.1039/C5CC02618K
Article type: Communication
Submitted: 31 Mar 2015
Accepted: 14 May 2015
First published: 15 May 2015

Download Citation

Chem. Commun., 2015,51, 9821-9824

Author version available

Download author version (PDF)

Permissions

Request permissions

Enabling [¹⁸F]-bicyclo[6.1.0]nonyne for oligonucleotide conjugation for positron emission tomography applications: [¹⁸F]-anti-microRNA-21 as an example

X. Li, A. Roivainen, J. Bergman, A. Heinonen, F. Bengel, T. Thum and J. Knuuti, Chem. Commun., 2015, 51, 9821 DOI: 10.1039/C5CC02618K

To request permission to reproduce material from this article, please go to the Copyright Clearance Center request page.

If you are an author contributing to an RSC publication, you do not need to request permission provided correct acknowledgement is given.

If you are the author of this article, you do not need to request permission to reproduce figures and diagrams provided correct acknowledgement is given. If you want to reproduce the whole article in a third-party publication (excluding your thesis/dissertation for which permission is not required) please go to the Copyright Clearance Center request page.

Social activity

Fetching data from CrossRef.
This may take some time to load.

Chemical Communications