Palladium-catalyzed asymmetric intermolecular Mizoroki–Heck reaction for the construction of a chiral quaternary carbon center is developed, affording 2,2-disubstituted 2,5-dihydrofurans in high yield with excellent enantioselectivity. The products are easily converted into the corresponding butenolides with retention of enantioselectivity.
Q. Zhang, S. Wan, D. Chen, C. Ding and X. Hou, Chem. Commun., 2015, 51, 12235 DOI: 10.1039/C5CC03601A
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