Issue 55, 2015
From the journal:

Chemical Communications

A microRNA-activated molecular machine for non-enzymatic target recycling amplification detection of microRNA from cancer cells†

Xin Li,a   Daxiu Li,a   Wenjiao Zhou,a   Yaqin Chai,a   Ruo Yuana  and  Yun Xiang*a  

* Corresponding authors

a Key Laboratory of Luminescent and Real-Time Analytical Chemistry, Ministry of Education, School of Chemistry and Chemical Engineering, Southwest University, Chongqing 400715, P. R. China
E-mail: yunatswu@swu.edu.cn
Fax: +86-23-68252277
Tel: +86-23-68253172

Abstract

The presence of the microRNA-141 target molecules activates the DNA molecular machine powered by the DNA fuel strands, leading to non-enzymatic target cyclic reuse of microRNA-141 and significantly amplified fluorescent signals for sensitive monitoring of microRNA-141 from low numbers of human prostate cancer cells.

Graphical abstract: A microRNA-activated molecular machine for non-enzymatic target recycling amplification detection of microRNA from cancer cells

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Article information

DOI
https://doi.org/10.1039/C5CC03723A
Article type
Communication
Submitted
05 May 2015
Accepted
27 May 2015
First published
12 Jun 2015

Chem. Commun., 2015,51, 11084-11087

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A microRNA-activated molecular machine for non-enzymatic target recycling amplification detection of microRNA from cancer cells

X. Li, D. Li, W. Zhou, Y. Chai, R. Yuan and Y. Xiang, Chem. Commun., 2015, 51, 11084 DOI: 10.1039/C5CC03723A

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