Issue 60, 2015
From the journal:

Chemical Communications

Gene delivery polymer structure–function relationships elucidated via principal component analysis†

C. J. Bishop,a   B. Abubaker-Sharif,a   T. Guiriba,b   S. Y. Tzenga  and  J. J. Green*abc  

* Corresponding authors

a The Johns Hopkins University School of Medicine, Department of Biomedical Engineering, Translational Tissue Engineering Center, 400 North Broadway, Baltimore MD, USA
E-mail: green@jhu.edu

b The Johns Hopkins University, Department of Materials Science and Engineering, 400 North Broadway, Baltimore MD, USA

c The Johns Hopkins University School of Medicine, Departments of Neurosurgery and Ophthalmology, 400 North Broadway, Baltimore MD, USA

Abstract

Principal component analysis was applied to a biomaterial library of poly(beta-amino ester)s, useful for non-viral gene delivery, to elucidate chemical parameters that drive biological function. Correlative relationships and principal components were analyzed between 24 physico-chemical polymer properties and 3 cell-based functional variables in human glioblastoma cells (transfection, uptake, and viability).

Graphical abstract: Gene delivery polymer structure–function relationships elucidated via principal component analysis

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Article information

DOI
https://doi.org/10.1039/C5CC04417K
Article type
Communication
Submitted
29 May 2015
Accepted
22 Jun 2015
First published
22 Jun 2015

Chem. Commun., 2015,51, 12134-12137

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Gene delivery polymer structure–function relationships elucidated via principal component analysis

C. J. Bishop, B. Abubaker-Sharif, T. Guiriba, S. Y. Tzeng and J. J. Green, Chem. Commun., 2015, 51, 12134 DOI: 10.1039/C5CC04417K

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