Design of a hyperpolarized 15N NMR probe that induces a large chemical-shift change upon binding of calcium ions

Abstract

Ca²⁺ is a fundamental metal ion for physiological functioning. Therefore, molecular probes for Ca²⁺ analysis are required. Recently, a hyperpolarized NMR probe has emerged as a promising tool. Here, we report a new design of a hyperpolarized NMR probe for Ca²⁺, which showed a large chemical shift change upon binding to Ca²⁺ and was applied for Ca²⁺ sensing in a hyperpolarized state.