The first total chemical synthesis of the site-selective azide-labeled [I66A]HIV-1 protease is described by native chemical ligation. Chemical synthesis of azide-labeled proteins would provide useful protein tools for biochemical, biophysical or medical studies.
![Graphical abstract: Total chemical synthesis of the site-selective azide-labeled [I66A]HIV-1 protease](/en/Image/Get?imageInfo.ImageType=GA&imageInfo.ImageIdentifier.ManuscriptID=C5CC04846J&imageInfo.ImageIdentifier.Year=2015)
Y. Qi, H. Chang, K. Pan, C. Tian and J. Zheng, Chem. Commun., 2015, 51, 14632 DOI: 10.1039/C5CC04846J
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