A novel dual-FRET-based fluorescence probe was designed and synthesized for the sequential detection of MMP-2 and caspase-3. This probe can successfully monitor Dox- and UV-induced cell apoptosis signals in real time and in situ, which demonstrated its great potential for apoptosis-related drug screening and dynamic apoptosis imaging.
S. Li, L. Liu, H. Cheng, B. Li, W. Qiu and X. Zhang, Chem. Commun., 2015, 51, 14520 DOI: 10.1039/C5CC04962H
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