Issue 74, 2015
From the journal:

Chemical Communications

Reversible DNA i-motif to hairpin switching induced by copper(ii) cations†

Henry Albert Day,a   Elisé Patricia Wright,a   Colin John MacDonald,a   Andrew James Gatesbc  and  Zoë Ann Ella Waller*ac  

* Corresponding authors

a School of Pharmacy, University of East Anglia, Norwich Research Park, Norwich, UK
E-mail: z.waller@uea.ac.uk

b School of Biological Sciences, University of East Anglia, Norwich Research Park, Norwich, UK

c Centre for Molecular and Structural Biochemistry, University of East Anglia, Norwich Research Park, Norwich, UK

Abstract

i-Motif DNA structures have previously been utilised for many different nanotechnological applications, but all have used changes in pH to fold the DNA. Herein we describe how copper(II) cations can alter the conformation of i-motif DNA into an alternative hairpin structure which is reversible by chelation with EDTA.

Graphical abstract: Reversible DNA i-motif to hairpin switching induced by copper(ii) cations

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Article information

DOI
https://doi.org/10.1039/C5CC05111H
Article type
Communication
Submitted
22 Jun 2015
Accepted
03 Aug 2015
First published
03 Aug 2015
This article is Open Access
Creative Commons BY license

Chem. Commun., 2015,51, 14099-14102

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Reversible DNA i-motif to hairpin switching induced by copper(II) cations

H. A. Day, E. P. Wright, C. J. MacDonald, A. J. Gates and Z. A. E. Waller, Chem. Commun., 2015, 51, 14099 DOI: 10.1039/C5CC05111H

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