Issue 80, 2015
From the journal:

Chemical Communications

Stable and compact zwitterionic polydiacetylene micelles with tumor-targeting properties†

Ioanna Theodorou,‡ab   Parambath Anilkumar,‡c   Benoit Lelandais,ab   Damien Clarisse,c   Anaëlle Doerflinger,c   Edmond Gravel,c   Frédéric Ducongé*ab  and  Eric Doris*c  

* Corresponding authors

a CEA, I2BM, Molecular Imaging Research Center (MIRCen), 18 route du panorama, BP no 6, 92265 Fontenay-aux-Roses, France

b CNRS, Unité de Recherche Associée CEA-CNRS2210, Université Paris Sud, 18 route du panorama, BP no 6, 92265 Fontenay-aux-Roses, France
E-mail: frederic.duconge@cea.fr

c CEA, IBITECS, Service de Chimie Bioorganique et de Marquage, 91191 Gif-sur-Yvette, France
E-mail: eric.doris@cea.fr

Abstract

Compact polymerized polydiacetylene-micelles with “stealth” zwitterionic surface coating were assembled and tested in a murine xenograft model of breast cancer. In vivo fluorescence imaging indicated accumulation in the tumor area and histological studies revealed predominant uptake of the micelles at the margins of the tumor, thereby allowing the delineation of its volume.

Graphical abstract: Stable and compact zwitterionic polydiacetylene micelles with tumor-targeting properties

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Article information

DOI
https://doi.org/10.1039/C5CC05333A
Article type
Communication
Submitted
30 Jun 2015
Accepted
11 Aug 2015
First published
11 Aug 2015

Chem. Commun., 2015,51, 14937-14940

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Stable and compact zwitterionic polydiacetylene micelles with tumor-targeting properties

I. Theodorou, P. Anilkumar, B. Lelandais, D. Clarisse, A. Doerflinger, E. Gravel, F. Ducongé and E. Doris, Chem. Commun., 2015, 51, 14937 DOI: 10.1039/C5CC05333A

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