Issue 73, 2015
From the journal:

Chemical Communications

TFA-promoted direct C–H sulfenylation at the C2 position of non-protected indoles†

Thomas Hostier,a   Vincent Ferey,b   Gino Ricci,c   Domingo Gomez Pardoa  and  Janine Cossy*a  

* Corresponding authors

a Laboratoire de Chimie Organique, Institute of Chemistry, Biology and Innovation (CBI), UMR 8231, ESPCI ParisTech/CNRS/PSL Research University, 10 rue Vauquelin, 75231-Paris Cedex 05, France
E-mail: janine.cossy@espci.fr

b Chemistry and Biotechnology Development, SANOFI, 371 rue du Professeur Blayac, 34184-Montpellier Cedex 04, France

c Sanofi Process Development, 45 Chemin de Mételine BP15, 04210-Sisteron Cedex, France

Abstract

A simple, efficient and practical metal-free C–H sulfenylation process at the C2 position of non-protected indoles has been developed. 2-Thioindoles were obtained in moderate to high yields using stable and readily available N-(thio)succinimides at room temperature in the presence of TFA.

Graphical abstract: TFA-promoted direct C–H sulfenylation at the C2 position of non-protected indoles

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Article information

DOI
https://doi.org/10.1039/C5CC05421D
Article type
Communication
Submitted
01 Jul 2015
Accepted
22 Jul 2015
First published
24 Jul 2015

Chem. Commun., 2015,51, 13898-13901

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TFA-promoted direct C–H sulfenylation at the C2 position of non-protected indoles

T. Hostier, V. Ferey, G. Ricci, D. G. Pardo and J. Cossy, Chem. Commun., 2015, 51, 13898 DOI: 10.1039/C5CC05421D

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