Issue 75, 2015
From the journal:

Chemical Communications

Electrochemically triggered release of human insulin from an insulin-impregnated reduced graphene oxide modified electrode†

Florina Teodorescu,a   Laure Rolland,b   Viswanatha Ramarao,a   Amar Abderrahmani,b   Daniel Mandler,c   Rabah Boukherrouba  and  Sabine Szunerits*a  

* Corresponding authors

a Institute d’Electronique, de Microélectronique et de Nanotechnologie (IEMN, UMR CNRS 8520), Université Lille 1, Cité Scientifique, Avenue Poincaré, BP 60069, 59652 Villeneuve d’Ascq, France
E-mail: sabine.szunerits@iri.univ-lille1.fr

b Univ. Lille, CNRS, CHU Lille, Institut Pasteur de Lille, European Genomic Institute of Diabetes (EGID) FR 3508, UMR 8199 – Génomique Intégrative et Modélisation des Maladies Métaboliques, F-59000 Lille, France

c Institute of Chemistry, The Hebrew University of Jerusalem, Jerusalem 9190401, Israel

Abstract

An electrochemical insulin-delivery system based on reduced graphene oxide impregnated with insulin is described. Upon application of a potential pulse of −0.8 V for 30 min, up to 70 ± 4% of human insulin was released into a physiological medium while preserving its biological activity.

Graphical abstract: Electrochemically triggered release of human insulin from an insulin-impregnated reduced graphene oxide modified electrode

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Article information

DOI
https://doi.org/10.1039/C5CC05539C
Article type
Communication
Submitted
08 Jul 2015
Accepted
30 Jul 2015
First published
30 Jul 2015

Chem. Commun., 2015,51, 14167-14170

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Electrochemically triggered release of human insulin from an insulin-impregnated reduced graphene oxide modified electrode

F. Teodorescu, L. Rolland, V. Ramarao, A. Abderrahmani, D. Mandler, R. Boukherroub and S. Szunerits, Chem. Commun., 2015, 51, 14167 DOI: 10.1039/C5CC05539C

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