Issue 94, 2015
From the journal:

Chemical Communications

A high stiffness bio-inspired hydrogel from the combination of a poly(amido amine) dendrimer with DOPA†

Yao Wang,ab   Qiang Zhao,ac   Yiyang Luo,ab   Zejun Xu,ab   He Zhang,d   Sheng Yang,*d   Yen Weie  and  Xinru Jia*ab  

* Corresponding authors

a Beijing National Laboratory for Molecular Sciences (BNLMS), College of Chemistry and Molecular Engineering, Peking University, Beijing 100871, P. R. China
E-mail: xrjia@pku.edu.cn

b Key Laboratory of Polymer Chemistry and Physics of the Ministry of Education, Peking University, Beijing 100871, P. R.China

c State Key Laboratory for Structural Chemistry of Unstable and Stable Species, Peking University, Beijing 100871, P. R. China

d Chongqing Key Laboratory for Oral Diseases and Biomedical Sciences, Chongqing Municipal Key Laboratory of Oral Biomedical Engineering of Higher Education, College of Stomatology, Chongqing Medical University, Chongqing 400016, P. R. China
E-mail: ysdentist@hotmail.com

e Department of Chemistry, Tsinghua University, Beijing 100084, P. R. China

Abstract

A robust biodegradable hydrogel is constructed from two components containing G4.0 PAMAM and DOPA, which displays excellent interconnected porous 3D networks, higher mechanical strength, low and stable swelling and good biocompatibility. A mouse CSD model in vivo evidences that moderate bone-like tissue and extensive bony tissue are observed when the hydrogel is implanted.

Graphical abstract: A high stiffness bio-inspired hydrogel from the combination of a poly(amido amine) dendrimer with DOPA

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Article information

DOI
https://doi.org/10.1039/C5CC05643H
Article type
Communication
Submitted
08 Jul 2015
Accepted
21 Sep 2015
First published
21 Sep 2015

Chem. Commun., 2015,51, 16786-16789

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A high stiffness bio-inspired hydrogel from the combination of a poly(amido amine) dendrimer with DOPA

Y. Wang, Q. Zhao, Y. Luo, Z. Xu, H. Zhang, S. Yang, Y. Wei and X. Jia, Chem. Commun., 2015, 51, 16786 DOI: 10.1039/C5CC05643H

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