A high yielding metal-catalysed Conia-ene reaction of 2-acetylenic ketones for the synthesis of bicyclo[3.n.1]alkenes has been developed. This simple and efficient 6-endo-dig-cyclization protocol enables the synthesis of a wide variety of bicyclic systems, present in many natural products.
![Graphical abstract: Synthesis of highly strained bicyclic[3.n.1]alkenes by a metal-catalyzed Conia-ene reaction](/en/Image/Get?imageInfo.ImageType=GA&imageInfo.ImageIdentifier.ManuscriptID=C5CC05926G&imageInfo.ImageIdentifier.Year=2015)
S. Kallepu, K. K. Gollapelli, J. B. Nanubolu and R. Chegondi, Chem. Commun., 2015, 51, 16840 DOI: 10.1039/C5CC05926G
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