Issue 78, 2015
From the journal:

Chemical Communications

An injectable drug-loaded hydrogel based on a supramolecular polymeric prodrug†

Lu Xiong,‡a   Qiaojie Luo,‡b   Ying Wang,a   Xiaodong Li,*b   Zhiquan Shena  and  Weipu Zhu*a  

* Corresponding authors

a MOE Key Laboratory of Macromolecular Synthesis and Functionalization, Department of Polymer Science and Engineering, Zhejiang University, Hangzhou 310027, People's Republic of China
E-mail: zhuwp@zju.edu.cn
Fax: +86 571 87953727
Tel: +86 571 87953739

b Affiliated Stomatology Hospital, School of Medicine, Zhejiang University, Hangzhou 310006, China
E-mail: cisarli@zju.edu.cn
Fax: +86 571 87217430
Tel: +86 571 87217430

Abstract

We reported a novel injectable doxorubicin-loaded hydrogel based on host–guest interaction and Schiff's base reaction. A supramolecular polymeric prodrug was prepared through the inclusion of adamantane-modified doxorubicin into the β-cyclodextrin cavity on the polyaldehyde dextran chain, which was in situ crosslinked by carboxymethyl chitosan.

Graphical abstract: An injectable drug-loaded hydrogel based on a supramolecular polymeric prodrug

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Article information

DOI
https://doi.org/10.1039/C5CC06025G
Article type
Communication
Submitted
20 Jul 2015
Accepted
05 Aug 2015
First published
07 Aug 2015

Chem. Commun., 2015,51, 14644-14647

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An injectable drug-loaded hydrogel based on a supramolecular polymeric prodrug

L. Xiong, Q. Luo, Y. Wang, X. Li, Z. Shen and W. Zhu, Chem. Commun., 2015, 51, 14644 DOI: 10.1039/C5CC06025G

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