Issue 76, 2015
From the journal:

Chemical Communications

Highly selective two-photon imaging of cysteine in cancerous cells and tissues†

Yun Hak Lee,‡a   Wen Xiu Ren,‡a   Jiyou Han,‡b   Kyoung Sunwoo,a   Ja-Yun Lim,b   Jong-Hoon Kim*b  and  Jong Seung Kim*a  

* Corresponding authors

a Department of Chemistry, Korea University, Seoul 136-701, Republic of Korea
E-mail: jongskim@korea.ac.kr
Fax: +82-2-3290-3121

b Division of Biotechnology, Laboratory of Stem Cells and Tissue Regeneration, College of Life Sciences & Biotechnology, Korea University, Seoul 136-713, Republic of Korea
E-mail: jhkim@korea.ac.kr
Fax: +82-2-3290-3507

Abstract

Abnormal concentrations of Cys have been reported to be implicated in various health problems, including cancer, neuropathy, and cardiomyopathy. We present a novel two-photon fluorescent probe for the specific recognition of cysteine over homocysteine and glutathione, and the bioapplication of this probe for the imaging of live cancerous cells and thick tissues.

Graphical abstract: Highly selective two-photon imaging of cysteine in cancerous cells and tissues

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Article information

DOI
https://doi.org/10.1039/C5CC06038A
Article type
Communication
Submitted
20 Jul 2015
Accepted
31 Jul 2015
First published
31 Jul 2015

Chem. Commun., 2015,51, 14401-14404

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Highly selective two-photon imaging of cysteine in cancerous cells and tissues

Y. H. Lee, W. X. Ren, J. Han, K. Sunwoo, J. Lim, J. Kim and J. S. Kim, Chem. Commun., 2015, 51, 14401 DOI: 10.1039/C5CC06038A

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