Issue 94, 2015
From the journal:

Chemical Communications

Dual fluorescent deoxyguanosine mimics for FRET detection of G-quadruplex folding†

Darian J. M. Blanchard,a   Thomas Z. Cservenyia  and  Richard A. Manderville*a  

* Corresponding authors

a Departments of Chemistry & Toxicology, University of Guelph, Guelph, Ontario, Canada N1G 2w1
E-mail: rmanderv@uoguelph.ca

Abstract

Replacement of deoxyguanosine (dG) nucleobases within G-tetrads of G-quadruplex folding oligonucleotides with donor (D)/acceptor (A) fluorescent 8aryldG residues provides diagnostic FRET signalling for G-quadruplex detection.

Graphical abstract: Dual fluorescent deoxyguanosine mimics for FRET detection of G-quadruplex folding

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Article information

DOI
https://doi.org/10.1039/C5CC07154B
Article type
Communication
Submitted
25 Aug 2015
Accepted
29 Sep 2015
First published
29 Sep 2015

Chem. Commun., 2015,51, 16829-16831

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Dual fluorescent deoxyguanosine mimics for FRET detection of G-quadruplex folding

D. J. M. Blanchard, T. Z. Cservenyi and R. A. Manderville, Chem. Commun., 2015, 51, 16829 DOI: 10.1039/C5CC07154B

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