Issue 92, 2015
From the journal:

Chemical Communications

Real-time monitoring of rolling circle amplification using aggregation-induced emission: applications in biological detection†

Hong-Xin Jiang,abc   Meng-Yao Zhao,abc   Chen-Di Niuabc  and  De-Ming Kong*abc  

* Corresponding authors

a State Key Laboratory of Medicinal Chemical Biology, Nankai University, Tianjin, People's Republic of China
E-mail: kongdem@nankai.edu.cn
Fax: +86-22-23502458

b Collaborative Innovation Center of Chemical Science and Engineering (Tianjin), Tianjin, People's Republic of China

c Tianjin Key Laboratory of Biosensing and Molecular Recognition, Research Centre for Analytical Sciences, Nankai University, Tianjin, People's Republic of China

Abstract

We report that QATPE, an aggregation-induced emission-active tetraphenylethene dye, can be used as a non-sequence-specific ssDNA probe for real-time monitoring of all rolling circle amplification (RCA) reactions, thus making RCA more suitable for biosensing applications.

Graphical abstract: Real-time monitoring of rolling circle amplification using aggregation-induced emission: applications in biological detection

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Article information

DOI
https://doi.org/10.1039/C5CC07340E
Article type
Communication
Submitted
01 Sep 2015
Accepted
18 Sep 2015
First published
18 Sep 2015

Chem. Commun., 2015,51, 16518-16521

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Real-time monitoring of rolling circle amplification using aggregation-induced emission: applications in biological detection

H. Jiang, M. Zhao, C. Niu and D. Kong, Chem. Commun., 2015, 51, 16518 DOI: 10.1039/C5CC07340E

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