Issue 15, 2015

Engineered biosynthesis of natural products in heterologous hosts

Abstract

Natural products produced by microorganisms and plants are a major resource of antibacterial and anticancer drugs as well as industrially useful compounds. However, the native producers often suffer from low productivity and titers. Here we summarize the recent applications of heterologous biosynthesis for the production of several important classes of natural products such as terpenoids, flavonoids, alkaloids, and polyketides. In addition, we will discuss the new tools and strategies at multi-scale levels including gene, pathway, genome and community levels for highly efficient heterologous biosynthesis of natural products.

Graphical abstract: Engineered biosynthesis of natural products in heterologous hosts

Article information

Article type
Review Article
Submitted
12 Jan 2015
First published
11 May 2015

Chem. Soc. Rev., 2015,44, 5265-5290

Engineered biosynthesis of natural products in heterologous hosts

Y. Luo, B. Li, D. Liu, L. Zhang, Y. Chen, B. Jia, B. Zeng, H. Zhao and Y. Yuan, Chem. Soc. Rev., 2015, 44, 5265 DOI: 10.1039/C5CS00025D

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