Towards the elaboration of new gold-based optical theranostics

Pierre-Emmanuel Doulain; Richard Decréau; Cindy Racoeur; Victor Goncalves; Laurence Dubrez; Ali Bettaieb; Pierre Le Gendre; Franck Denat; Catherine Paul; Christine Goze; Ewen Bodio

doi:10.1039/C4DT02977A

Towards the elaboration of new gold-based optical theranostics†

Pierre-Emmanuel Doulain,^a Richard Decréau,^a Cindy Racoeur,^bc Victor Goncalves,^a Laurence Dubrez,^de Ali Bettaieb,^bc Pierre Le Gendre,^a Franck Denat,^a Catherine Paul,*^bc Christine Goze*^a and Ewen Bodio*^a

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^a Institut de Chimie Moléculaire de l'Université de Bourgogne, UMR 6302 CNRS, Université de Bourgogne, 9 avenue Alain Savary, BP 47870, 21080 Dijon Cedex, France
E-mail: ewen.bodio@u-bourgogne.fr, christine.goze@u-bourgogne.fr

^b EPHE, Paris, France

^c EA7269 EPHE-University of burgundy, University of Burgundy, Dijon, France
E-mail: catherine.paul@u-bourgogne.fr

^d Institut National de la Santé et de la Recherche Médicale (Inserm) UMR866, Faculty of Medecine, Dijon, France

^e Université de Bourgogne, Institut Fédératif de Recherche (IFR) 100, Dijon, France

Abstract

Four new red BODIPY–gold(I) theranostic compounds were synthesized. Some of them were vectorized by tethering a biovector (glucose or bombesin derivatives) to the metallic center. Their photophysical properties were studied. Additionally, their cytotoxicity was examined on different cancer cell lines and on a normal cell line, they were tracked in vitro by fluorescence detection, and their uptake was evaluated by ICP-MS measurements.

This article is part of the themed collection: Dalton Discussion 15: Metal ions in medical imaging

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Towards the elaboration of new gold-based optical theranostics†

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