Further to the introduction of solvent and reagent guides at GSK, the reagent guide methodology has been adapted to score common acids and bases for use in situations where the chemistry is tolerant of a number of options. The pKa of each acid and base, and information as to whether they are generally recognised as safe are included to enhance the utility of such guides.
R. K. Henderson, A. P. Hill, A. M. Redman and H. F. Sneddon, Green Chem., 2015, 17, 945 DOI: 10.1039/C4GC01481B
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