A sustainable, efficient method for the chemoselective N-functionalization of isatins based on the use of KF-Celite in 2-methyltetrahydrofuran is reported. Notably, the protocol allows reactions with a wide range of electrophiles such as alkyl halides, isocyanates and Michael acceptors.
A. D. Mamuye, S. Monticelli, L. Castoldi, W. Holzer and V. Pace, Green Chem., 2015, 17, 4194 DOI: 10.1039/C5GC01002K
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