Microfluidic platforms with monolithically integrated hierarchical apertures for the facile and rapid formation of cargo-carrying vesicles

Hyesung Cho; Junsoo Kim; Keishi Suga; Takaaki Ishigami; Hyunchul Park; Jung Won Bang; Soonmin Seo; Mansoo Choi; Pahn-Shick Chang; Hiroshi Umakoshi; Ho-Sup Jung; Kahp-Yang Suh

doi:10.1039/C4LC01096E

Microfluidic platforms with monolithically integrated hierarchical apertures for the facile and rapid formation of cargo-carrying vesicles

Hyesung Cho,†^ab Junsoo Kim,†^d Keishi Suga,†^e Takaaki Ishigami,^e Hyunchul Park,^f Jung Won Bang,^bc Soonmin Seo,^g Mansoo Choi,^abc Pahn-Shick Chang,^h Hiroshi Umakoshi,*^e Ho-Sup Jung*^a and Kahp-Yang Suh ‡^a

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* Corresponding authors

^a Department of Mechanical and Aerospace Engineering, Seoul National University, Seoul, Republic of Korea
E-mail: jhs@snu.ac.kr

^b Global Frontier Center for Multiscale Energy Systems, Seoul National University, Seoul 151-744, Republic of Korea

^c Division of WCU Multiscale Mechanical Design, Department of Mechanical and Aerospace Engineering, Seoul National University, Seoul, Republic of Korea

^d Energy Harvesting Devices Research Section, Electronics and Telecommunications Research Institute, Daejeon 305-700, Republic of Korea

^e Division of Chemical Engineering, Graduate School of Engineering Science, Osaka University, Osaka, Japan
E-mail: Hiroshi.Umakoshi@cheng.es.osaka-u.ac.jp

^f Center for Materials Architecturing, Korea Institute of Science and Technology, Seoul 136-791, Republic of Korea

^g College of BioNano Technology, Gachon University, Gyeonggi, Republic of Korea

^h Department of Agricultural Biotechnology, Seoul National University, Seoul, Republic of Korea

Abstract

We fabricated a simple yet robust microfluidic platform with monolithically integrated hierarchical apertures. This platform showed efficient diffusive mixing of the introduced lipids through approximately 8000 divisions with tiny pores (~5 μm in diameter), resulting in massive, real-time production of various cargo-carrying particles via multi-hydrodynamic focusing.

Lab on a Chip

Microfluidic platforms with monolithically integrated hierarchical apertures for the facile and rapid formation of cargo-carrying vesicles

Abstract

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