Issue 4, 2015
From the journal:

MedChemComm

A solid- and solution-phase-based library of 2β-methyl substituted penicillin derivatives and their effects on growth inhibition of tumor cell lines†

Dora B. Boggián,a   Patricia G. Cornier,a   Ernesto G. Mata,*a   Viviana C. Blank,b   Mariano G. Cárdenasb  and  Leonor P. Roguin*b  

* Corresponding authors

a Instituto de Química Rosario (CONICET – UNR), Facultad de Ciencias Bioquímicas y Farmacéuticas, Universidad Nacional de Rosario, Suipacha 531, 2000 Rosario, Argentina
E-mail: mata@iquir-conicet.gov.ar

b Instituto de Química y Fisicoquímica Biológicas (UBA – CONICET), Facultad de Farmacia y Bioquímica. Universidad de Buenos Aires, Junín 956, C1113AAD Buenos Aires, Argentina

Abstract

We described the design, synthesis and antiproliferative properties of a series of twenty 2β-methyl substituted penicillin derivatives. This analysis includes evaluation against HeLa and MCF-7 human tumor cell lines and LM3 and B16-F0 murine tumor cell lines. The epithelial cell line derived from the normal mammary gland of mice (NMuMG) and the mouse embryo fibroblastcell line (3T3) were used as controls (non-cancer cells).

Graphical abstract: A solid- and solution-phase-based library of 2β-methyl substituted penicillin derivatives and their effects on growth inhibition of tumor cell lines

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Article information

DOI
https://doi.org/10.1039/C4MD00430B
Article type
Concise Article
Submitted
25 Sep 2014
Accepted
15 Dec 2014
First published
15 Dec 2014

Med. Chem. Commun., 2015,6, 619-625

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A solid- and solution-phase-based library of 2β-methyl substituted penicillin derivatives and their effects on growth inhibition of tumor cell lines

D. B. Boggián, P. G. Cornier, E. G. Mata, V. C. Blank, M. G. Cárdenas and L. P. Roguin, Med. Chem. Commun., 2015, 6, 619 DOI: 10.1039/C4MD00430B

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