Issue 3, 2015

Highly fluorescent and bioresorbable polymeric nanoparticles with enhanced photostability for cell imaging

Abstract

We report a facile and general strategy for enhancing the photostability of organic fluorophores for bioimaging applications. As a proof of concept, bright and robust fluorescence was observed in solid states of a well-defined synthetic polymer polycaprolactone consisting of di(thiophene-2-yl)-diketopyrrolopyrrole covalently linked in the middle of the polymer chain as a biocompatible and bioresorbable matrix. The nanoparticles prepared through a nanoprecipitation process of these polymers could be internalized by both tumor cells and stem cells with little cytotoxicity. Moreover, these highly fluorescent nanoparticles exhibited significantly enhanced photostability compared to commercial quantum dots or physical blends of dye/polymer complexes in cell imaging and long-term tracing.

Graphical abstract: Highly fluorescent and bioresorbable polymeric nanoparticles with enhanced photostability for cell imaging

Supplementary files

Article information

Article type
Communication
Submitted
23 Sep 2014
Accepted
07 Nov 2014
First published
17 Nov 2014

Nanoscale, 2015,7, 889-895

Author version available

Highly fluorescent and bioresorbable polymeric nanoparticles with enhanced photostability for cell imaging

S. Huang, S. Liu, K. Wang, C. Yang, Y. Luo, Y. Zhang, B. Cao, Y. Kang and M. Wang, Nanoscale, 2015, 7, 889 DOI: 10.1039/C4NR05576D

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