Synthesis and application of glycoconjugate-functionalized magnetic nanoparticles as potent anti-adhesion agents for reducing enterotoxigenic Escherichia coli infections

Yash S. Raval; Roland Stone; Benjamin Fellows; Bin Qi; Guohui Huang; O. Thompson Mefford; Tzuen-Rong J. Tzeng

doi:10.1039/C5NR00511F

You do not have JavaScript enabled. Please enable JavaScript to access the full features of the site or access our non-JavaScript page.

Synthesis and application of glycoconjugate-functionalized magnetic nanoparticles as potent anti-adhesion agents for reducing enterotoxigenic Escherichia coli infections†

Yash S. Raval,^a Roland Stone,^bc Benjamin Fellows,^bc Bin Qi,

^bc Guohui Huang,

^a O. Thompson Mefford^bc and Tzuen-Rong J. Tzeng*^a

Author affiliations

* Corresponding authors

^a Department of Biological Sciences, Clemson University, Clemson, SC 29634, USA
E-mail: tzuenrt@clemson.edu

^b Department of Materials Science and Engineering, Clemson University, Clemson, SC 29634, USA

^c Center for Optical Materials Science and Engineering Technologies (COMSET), Clemson University, 91 Technology Drive, Anderson, SC 29625, USA

Abstract

Polyethylene oxide stabilized magnetic nanoparticles (PEO-MNPs) bio-functionalized with glycoconjugate (Neu5Ac(α2-3)Gal(β1-4)Glcβ-sp) (GM3-MNPs) are synthesized using click chemistry. Interaction of GM3-MNPs with Enterotoxigenic Escherichia coli (ETEC) strain K99 (EC K99) is investigated using different microscopic techniques. Our results suggest that GM3-MNPs can effectively act as non-antibiotic anti-adhesion agents for treating ETEC infections.

Download options Please wait...

Supplementary files

Supplementary information PDF (348K)

Article information

DOI: https://doi.org/10.1039/C5NR00511F
Article type: Communication
Submitted: 22 Jan 2015
Accepted: 13 Apr 2015
First published: 14 Apr 2015

Download Citation

Nanoscale, 2015,7, 8326-8331

Author version available

Download author version (PDF)

Permissions

Request permissions

Synthesis and application of glycoconjugate-functionalized magnetic nanoparticles as potent anti-adhesion agents for reducing enterotoxigenic Escherichia coli infections

Y. S. Raval, R. Stone, B. Fellows, B. Qi, G. Huang, O. T. Mefford and T. J. Tzeng, Nanoscale, 2015, 7, 8326 DOI: 10.1039/C5NR00511F

To request permission to reproduce material from this article, please go to the Copyright Clearance Center request page.

If you are an author contributing to an RSC publication, you do not need to request permission provided correct acknowledgement is given.

If you are the author of this article, you do not need to request permission to reproduce figures and diagrams provided correct acknowledgement is given. If you want to reproduce the whole article in a third-party publication (excluding your thesis/dissertation for which permission is not required) please go to the Copyright Clearance Center request page.

Social activity

Fetching data from CrossRef.
This may take some time to load.

Nanoscale

Synthesis and application of glycoconjugate-functionalized magnetic nanoparticles as potent anti-adhesion agents for reducing enterotoxigenic Escherichia coli infections†

Abstract

Supplementary files

Article information

Download Citation

Author version available

Permissions

Synthesis and application of glycoconjugate-functionalized magnetic nanoparticles as potent anti-adhesion agents for reducing enterotoxigenic Escherichia coli infections

Social activity

Search articles by author

Spotlight

Advertisements