Issue 29, 2015
From the journal:

Nanoscale

Effective delivery of a rationally designed intracellular peptide drug with gold nanoparticle–peptide hybrids†

Daiyoon Lee,‡ab   Jinbo Zhao,‡a   Hong Yang,a   Shuyun Xu,a   Hyunhee Kim,ac   Shaun Pacheco,ac   Shaf Keshavjeeab  and  Mingyao Liu*abc  

* Corresponding authors

a Toronto General Research Institute, University Health Network, Toronto, ON, Canada
E-mail: mingyao.liu@utoronto.ca

b Institute of Medical Science, University of Toronto, Toronto, ON, Canada

c Department of Physiology, University of Toronto, Toronto, ON, Canada
E-mail: mingyao.liu@utoronto.ca

Abstract

A novel gold nanoparticle–peptide hybrid strategy was developed to intracellularly deliver a potent PKCδ inhibitor peptide for the treatment of acute lung injury. The gold nanoparticle–peptide hybrids showed good stability with high uptake, and demonstrated in vitro and in vivo efficacy. Our formulation strategy shows great promise in intracellular delivery of peptides.

Graphical abstract: Effective delivery of a rationally designed intracellular peptide drug with gold nanoparticle–peptide hybrids

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Article information

DOI
https://doi.org/10.1039/C5NR02377G
Article type
Communication
Submitted
13 Apr 2015
Accepted
25 Jun 2015
First published
07 Jul 2015

Nanoscale, 2015,7, 12356-12360

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Effective delivery of a rationally designed intracellular peptide drug with gold nanoparticle–peptide hybrids

D. Lee, J. Zhao, H. Yang, S. Xu, H. Kim, S. Pacheco, S. Keshavjee and M. Liu, Nanoscale, 2015, 7, 12356 DOI: 10.1039/C5NR02377G

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