Nanomechanical clues from morphologically normal cervical squamous cells could improve cervical cancer screening

Li Geng; Jiantao Feng; Quanmei Sun; Jing Liu; Wenda Hua; Jing Li; Zhuo Ao; Ke You; Yanli Guo; Fulong Liao; Youyi Zhang; Hongyan Guo; Jinsong Han; Guangwu Xiong; Lufang Zhang; Dong Han

doi:10.1039/C5NR03662C

Nanomechanical clues from morphologically normal cervical squamous cells could improve cervical cancer screening†

Li Geng,‡^a Jiantao Feng,‡^b Quanmei Sun,^b Jing Liu,^c Wenda Hua,^d Jing Li,^b Zhuo Ao,^b Ke You,^a Yanli Guo,^a Fulong Liao,^b Youyi Zhang,^a Hongyan Guo,^a Jinsong Han,^a Guangwu Xiong,^a Lufang Zhang^a and Dong Han*^b

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* Corresponding authors

^a Peking University Third Hospital, Beijing, China 100191

^b National Center for Nanoscience and Technology, Beijing, China 100190
E-mail: dhan@nanoctr.cn

^c University of Chinese Academy of Sciences, Beijing, China 100049

^d First Affiliated Hospital of Kunming Medical University, Kunming, China 650032

Abstract

Applying an atomic force microscope, we performed a nanomechanical analysis of morphologically normal cervical squamous cells (MNSCs) which are commonly used in cervical screening. Results showed that nanomechanical parameters of MNSCs correlate well with cervical malignancy, and may have potential in cancer screening to provide early diagnosis.

Nanoscale

Nanomechanical clues from morphologically normal cervical squamous cells could improve cervical cancer screening†

Abstract

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Nanomechanical clues from morphologically normal cervical squamous cells could improve cervical cancer screening

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