Issue 41, 2015

Micro-optical coherence tomography tracking of magnetic gene transfection via Au–Fe3O4 dumbbell nanoparticles

Abstract

Heterogeneous Au–Fe3O4 dumbbell nanoparticles (NPs) are composed of Au NPs and Fe3O4 NPs that bring in optical and magnetic properties respectively. This article reports the engineering of Au–Fe3O4 NPs as gene carriers for magnetic gene transfection as well as contrast agents for micro-optical coherence tomography (μOCT). As a proof-of-concept, Au–Fe3O4 NPs are used to deliver the green fluorescent protein to HEK 293T cells and their entrance into the cells is monitored through μOCT.

Graphical abstract: Micro-optical coherence tomography tracking of magnetic gene transfection via Au–Fe3O4 dumbbell nanoparticles

Supplementary files

Article information

Article type
Communication
Submitted
12 Aug 2015
Accepted
23 Sep 2015
First published
23 Sep 2015

Nanoscale, 2015,7, 17249-17253

Micro-optical coherence tomography tracking of magnetic gene transfection via Au–Fe3O4 dumbbell nanoparticles

W. Shi, X. Liu, C. Wei, Z. J. Xu, S. S. W. Sim, L. Liu and C. Xu, Nanoscale, 2015, 7, 17249 DOI: 10.1039/C5NR05459A

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