Issue 4, 2015

Anionic glycolipids related to glucuronosyldiacylglycerol inhibit protein kinase Akt

Abstract

New glucuronosyldiacylglycerol (GlcADG) analogues based on a 2-O-β-D-glucopyranosyl-sn-glycerol scaffold and carrying one or two acyl chains of different lengths have been synthesized as phosphatidylinositol 3-phosphate (PI3P) mimics targeting the protein kinase Akt. The Akt inhibitory effect of the prepared compounds was assayed using an in vitro kinase assay. The antiproliferative activity of the compounds was tested in the human ovarian carcinoma IGROV-1 cell line in which we found that two of them could inhibit proliferation, in keeping with the target inhibitory effect.

Graphical abstract: Anionic glycolipids related to glucuronosyldiacylglycerol inhibit protein kinase Akt

Supplementary files

Article information

Article type
Paper
Submitted
28 Jul 2014
Accepted
06 Nov 2014
First published
06 Nov 2014

Org. Biomol. Chem., 2015,13, 1091-1099

Author version available

Anionic glycolipids related to glucuronosyldiacylglycerol inhibit protein kinase Akt

M. Vetro, B. Costa, G. Donvito, N. Arrighetti, L. Cipolla, P. Perego, F. Compostella, F. Ronchetti and D. Colombo, Org. Biomol. Chem., 2015, 13, 1091 DOI: 10.1039/C4OB01602E

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