Issue 3, 2015
From the journal:

Organic & Biomolecular Chemistry

Rapid synthesis of isoquinolinones by intramolecular coupling of amides and ketones†

Wen-Tao Wei,a   Yu Liu,a   Lin-Miao Ye,a   Rong-Hui Lei,a   Xue-Jing Zhanga  and  Ming Yan*a  

* Corresponding authors

a Institute of Drug Synthesis and Pharmaceutical Process, School of Pharmaceutical Sciences, Sun Yat-sen University, Guangzhou 510006, China
E-mail: yanming@mail.sysu.edu.cn
Fax: +86-20-39943049

Abstract

Amides and ketones were intramolecularly coupled in the presence of KOt-Bu/DMF. The reaction provided good yields of a variety of isoquinolinones. A reaction mechanism of radical addition and subsequent E2-elimination is proposed.

Graphical abstract: Rapid synthesis of isoquinolinones by intramolecular coupling of amides and ketones

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Article information

DOI
https://doi.org/10.1039/C4OB01948B
Article type
Paper
Submitted
15 Sep 2014
Accepted
30 Oct 2014
First published
30 Oct 2014

Org. Biomol. Chem., 2015,13, 817-824

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Rapid synthesis of isoquinolinones by intramolecular coupling of amides and ketones

W. Wei, Y. Liu, L. Ye, R. Lei, X. Zhang and M. Yan, Org. Biomol. Chem., 2015, 13, 817 DOI: 10.1039/C4OB01948B

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