A simple reaction of some oxindole derivatives with 1,2-diaza-1,3-dienes to produce 2-oxo-spiro[indole-3,4′-pyridines] in good yields is described here. This transformation represents a practical two steps approach to new and biologically interesting 2-oxo-spiro[indole-3,4′-pyridine] scaffolds using a double Michael addition/cyclization sequence.
![Graphical abstract: Synthesis of novel symmetrical 2-oxo-spiro[indole-3,4′-pyridines] by a reaction of oxindoles with 1,2-diaza-1,3-dienes](/en/Image/Get?imageInfo.ImageType=GA&imageInfo.ImageIdentifier.ManuscriptID=C4OB01959H&imageInfo.ImageIdentifier.Year=2015)
O. A. Attanasi, L. A. Campisi, L. De Crescentini, G. Favi and F. Mantellini, Org. Biomol. Chem., 2015, 13, 277 DOI: 10.1039/C4OB01959H
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