A highly regio- and stereo-selective synthesis of cyclic β-D-glucosides 3via Pd(0)-catalyzed coupling cyclization of allenyl β-D-glucoside 1 and organic iodides in 20–38% yields is reported. After the deacetylation of 3, we obtained cyclic β-D-glucoses 4 in 90–97% yields, which may have SGLT2 inhibition activities.
X. Huang, C. Fu and S. Ma, Org. Biomol. Chem., 2015, 13, 248 DOI: 10.1039/C4OB01975J
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