An efficient method for the synthesis of spiro-N,O-ketals with 5- and 6-membered rings was developed via a gold-catalyzed spiroamidoketalization of alkynyl amidoalcohols under mild conditions. This methodology has been successfully applied to the synthesis of a spiro-N,O-ketal analogue of marineosin A.
M. Grammatikopoulou, S. Thysiadis and V. Sarli, Org. Biomol. Chem., 2015, 13, 1169 DOI: 10.1039/C4OB02050B
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