An enantioselective total synthesis of Sch-725674, a unique 14-membered macrolactone, has been accomplished in 13 steps. The step-wise dithiane alkylation served as a strategic step to assemble the upper and lower fragments of the molecule, whereas cross metathesis reaction, Yamaguchi macrolactonization and a substrate controlled stereoselective reduction are used as key steps to complete the total synthesis.
K. Ramakrishna and K. P. Kaliappan, Org. Biomol. Chem., 2015, 13, 234 DOI: 10.1039/C4OB02136C
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