Issue 9, 2015
From the journal:

Organic & Biomolecular Chemistry

Synthesis of a β-CCT-lanthanide conjugate for binding the dopamine transporter†

Gregory R. Naumiec,a   Grace Lincourt,a   Jeremy P. Clever,b   Michael A. McGregor,a   Abraham Kovoorbc  and  Brenton DeBoef*a  

* Corresponding authors

a Department of Chemistry, University of Rhode Island, 51 Lower College Road, Kingston, Rhode Island 02881, USA
E-mail: bdeboef@chm.uri.edu
Fax: +1-401-874-5072
Tel: +1-401-874-9480

b Kovogen, LLC, 168 Long Wharf Drive, Mystic, Connecticut 06355, USA

c Department of Biomedical and Pharmaceutical Sciences, University of Rhode Island, 41 Lower College Road, Kingston, Rhode Island 02881, USA

Abstract

The development of a β-CCT-lanthanide conjugate that binds the dopamine transporter (DAT) with high affinity (Kd = 303 nM) is described. Contrast agents such as the one described herein could be used as molecular probes to directly study the binding of small molecules to receptors such as DAT via MRI, PET or SPECT.

Graphical abstract: Synthesis of a β-CCT-lanthanide conjugate for binding the dopamine transporter

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Article information

DOI
https://doi.org/10.1039/C4OB02165G
Article type
Communication
Submitted
09 Oct 2014
Accepted
07 Jan 2015
First published
07 Jan 2015

Org. Biomol. Chem., 2015,13, 2537-2540

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Synthesis of a β-CCT-lanthanide conjugate for binding the dopamine transporter

G. R. Naumiec, G. Lincourt, J. P. Clever, M. A. McGregor, A. Kovoor and B. DeBoef, Org. Biomol. Chem., 2015, 13, 2537 DOI: 10.1039/C4OB02165G

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