Issue 7, 2015

A Sc(OTf)3-catalyzed cascade reaction of o-aminoacetophenone with methanamine: construction of dibenzo[b,h][1,6]naphthyridine derivatives

Abstract

An unexpected Sc(OTf)3-catalyzed and air-mediated cascade reaction of o-aminoacetophenones with methanamines was discovered as an efficient synthetic approach to a novel class of fluorescent fused-four-ring dibenzo[b,h][1,6]naphthyridine derivatives. Two possible mechanisms of the reaction were proposed. The photophysical properties of the dibenzo[b,h][1,6]naphthyridine 1a were initially considered.

Graphical abstract: A Sc(OTf)3-catalyzed cascade reaction of o-aminoacetophenone with methanamine: construction of dibenzo[b,h][1,6]naphthyridine derivatives

Supplementary files

Article information

Article type
Paper
Submitted
19 Oct 2014
Accepted
03 Dec 2014
First published
03 Dec 2014

Org. Biomol. Chem., 2015,13, 2122-2128

A Sc(OTf)3-catalyzed cascade reaction of o-aminoacetophenone with methanamine: construction of dibenzo[b,h][1,6]naphthyridine derivatives

D. Mao, J. Tang, W. Wang, X. Liu, S. Wu, J. Yu and L. Wang, Org. Biomol. Chem., 2015, 13, 2122 DOI: 10.1039/C4OB02220C

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