Issue 10, 2015
From the journal:

Organic & Biomolecular Chemistry

Total synthesis of a thromboxane receptor antagonist, terutroban†

Wasim Ahmed,ab   Prathama S. Mainkar,a   Srihari Pabbarajaa  and  Srivari Chandrasekhar*ab  

* Corresponding authors

a Division of Natural Products Chemistry, CSIR-Indian Institute of Chemical Technology, Tarnaka, Hyderabad, India 500 007
E-mail: srivaric@iict.res.in
Fax: +91-40-27160152
Tel: +91-40-27193210, 27193434

b Academy of Scientific and Innovative Research, New Delhi, India

Abstract

A total synthesis of terutroban is achieved using the Claisen rearrangement, Friedel–Crafts acylation and Heck coupling as key reactions, avoiding the classical Diels–Alder approach used before.

Graphical abstract: Total synthesis of a thromboxane receptor antagonist, terutroban

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Article information

DOI
https://doi.org/10.1039/C4OB02302A
Article type
Paper
Submitted
29 Oct 2014
Accepted
06 Jan 2015
First published
06 Jan 2015

Org. Biomol. Chem., 2015,13, 2951-2957

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Total synthesis of a thromboxane receptor antagonist, terutroban

W. Ahmed, P. S. Mainkar, S. Pabbaraja and S. Chandrasekhar, Org. Biomol. Chem., 2015, 13, 2951 DOI: 10.1039/C4OB02302A

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