Issue 8, 2015

Palladium-catalyzed oxidative deacetonative coupling of 4-aryl-2-methyl-3-butyn-2-ols with H-phosphonates

Abstract

An efficient and generally applicable protocol for palladium-catalyzed oxidative deacetonative coupling of 4-aryl-2-methyl-3-butyn-2-ols with dialkyl H-phosphonates has been developed. This methodology provides a new and practical route to alkynylphosphonates using the inexpensive 4-aryl-2-methyl-3-butyn-2-ols as the alkyne sources. This reaction could also be performed with aryl bromides, 2-methyl-3-butyne-2-ol and dialkyl H-phosphonates using the cheap 2-methyl-3-butyne-2-ol as an alkyne source.

Graphical abstract: Palladium-catalyzed oxidative deacetonative coupling of 4-aryl-2-methyl-3-butyn-2-ols with H-phosphonates

Supplementary files

Article information

Article type
Paper
Submitted
15 Nov 2014
Accepted
18 Dec 2014
First published
18 Dec 2014

Org. Biomol. Chem., 2015,13, 2432-2436

Author version available

Palladium-catalyzed oxidative deacetonative coupling of 4-aryl-2-methyl-3-butyn-2-ols with H-phosphonates

X. Li, S. Sun, F. Yang, J. Kang, Y. Wu and Y. Wu, Org. Biomol. Chem., 2015, 13, 2432 DOI: 10.1039/C4OB02410A

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