Both heat shock protein 90 and 70 (Hsp90, Hsp70) are cytoprotective proteins that regulate cell death by stabilizing and folding proteins. Taking a two-pronged approach, involving simultaneous inhibition of Hsp90 and Hsp70, leads to synergistic cell death, which makes this is an appealing clinical therapy.
Y. Wang and S. R. McAlpine, Org. Biomol. Chem., 2015, 13, 2108 DOI: 10.1039/C4OB02531H
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