Issue 10, 2015

Synthesis and DNA binding profile of N-mono- and N,N′-disubstituted indolo[3,2-b]carbazoles

Abstract

A series of N-monosubstituted and N,N′-disubstituted derivatives of the indolo[3,2-b]carbazole chromophore have been prepared, and their binding affinity for duplex DNA has been evaluated by ultraviolet and fluorescence spectroscopies. It has been found that indolo[3,2-b]carbazoles bearing basic N-alkyl substituents are intercalators that bind DNA with affinities in the micromolar and submicromolar range and a preference for associating with sequences of mixed composition and purine-pyrimidine steps.

Graphical abstract: Synthesis and DNA binding profile of N-mono- and N,N′-disubstituted indolo[3,2-b]carbazoles

Supplementary files

Article information

Article type
Communication
Submitted
09 Dec 2014
Accepted
22 Jan 2015
First published
22 Jan 2015

Org. Biomol. Chem., 2015,13, 2879-2883

Author version available

Synthesis and DNA binding profile of N-mono- and N,N′-disubstituted indolo[3,2-b]carbazoles

H. K. Panesar, J. Solano and T. G. Minehan, Org. Biomol. Chem., 2015, 13, 2879 DOI: 10.1039/C4OB02566K

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