Issue 9, 2015
From the journal:

Organic & Biomolecular Chemistry

Cyclopropanation using flow-generated diazo compounds†

Nuria M. Roda,a   Duc N. Tran,a   Claudio Battilocchio,a   Ricardo Labes,a   Richard J. Ingham,a   Joel M. Hawkinsb  and  Steven V. Ley*a  

* Corresponding authors

a Innovative Technology Centre, Department of Chemistry, University of Cambridge, Lensfield Road, Cambridge CB2 1EW, UK
E-mail: svl1000@cam.ac.uk
Web: http://www.leygroup.ch.cam.ac.uk/

b Pfizer Worldwide Research and Development, Eastern Point Road, Groton, CT 06340, USA

Abstract

We have devised a room temperature process for the cyclopropanation of electron-poor olefins using unstabilised diazo compounds, generated under continuous flow conditions. This protocol was applied to a wide range of different diazo species to generate functionalised cyclopropanes which are valuable 3D building blocks.

Graphical abstract: Cyclopropanation using flow-generated diazo compounds

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Article information

DOI
https://doi.org/10.1039/C5OB00019J
Article type
Communication
Submitted
06 Jan 2015
Accepted
06 Jan 2015
First published
07 Jan 2015
This article is Open Access
Creative Commons BY license

Org. Biomol. Chem., 2015,13, 2550-2554

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Cyclopropanation using flow-generated diazo compounds

N. M. Roda, D. N. Tran, C. Battilocchio, R. Labes, R. J. Ingham, J. M. Hawkins and S. V. Ley, Org. Biomol. Chem., 2015, 13, 2550 DOI: 10.1039/C5OB00019J

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