We report the synthesis and genetic encoding of a recently discovered post-translational modification, 2-hydroxyisobutyryl-lysine, to the genetic code of E. coli. The production of homogeneous proteins containing this amino acid will facilitate the study of modification in full-length proteins.
W. A. Knight and T. A. Cropp, Org. Biomol. Chem., 2015, 13, 6479 DOI: 10.1039/C5OB00283D
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