An artificial metathesase results from incorporation of an Hoveyda-Grubbs catalyst bearing an arylsulfonamide anchor within human carbonic anhydrase II. The optimization of the catalytic performance is achieved upon combining both chemical and genetic means. Up to 28 TONs were obtained within four hours under aerobic physiological conditions.
J. Zhao, A. Kajetanowicz and T. R. Ward, Org. Biomol. Chem., 2015, 13, 5652 DOI: 10.1039/C5OB00428D
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