Issue 18, 2015
From the journal:

Organic & Biomolecular Chemistry

Metal-free cascade cyclization of alkenes toward perfluorinated oxindoles†

Shi Tang,*ac   Zhi-Hao Li,a   Ming-Wei Wang,a   Zhi-Ping Lia  and  Rui-Long Shengb  

* Corresponding authors

a College of Chemistry and Chemical Engineering, Jishou University, Jishou 416000, China
E-mail: stang@jsu.edu.cn

b Shanghai Institute of Organic Chemistry, Chinese Academy of Sciences, 345 Lingling Road, Shanghai, China

c College of Chemistry and Chemical Engineering, Central South University, Changsha 410083, China

Abstract

A simple AIBN-mediated cyclization reaction of activated alkenes toward perfluorinated oxindoles is developed. In the presence of readily available AIBN, N-arylacrylamide and perfluoroalkyl iodides underwent perfluorination reaction to give perfluorinated oxindoles in good to excellent yields under metal-free conditions.

Graphical abstract: Metal-free cascade cyclization of alkenes toward perfluorinated oxindoles

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Article information

DOI
https://doi.org/10.1039/C5OB00454C
Article type
Paper
Submitted
06 Mar 2015
Accepted
30 Mar 2015
First published
30 Mar 2015

Org. Biomol. Chem., 2015,13, 5285-5288

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Metal-free cascade cyclization of alkenes toward perfluorinated oxindoles

S. Tang, Z. Li, M. Wang, Z. Li and R. Sheng, Org. Biomol. Chem., 2015, 13, 5285 DOI: 10.1039/C5OB00454C

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