A mild catalyst system for the synthesis of chiral amino alcohols via asymmetric transfer hydrogenation (ATH) of α-phthalimide ketones has been developed by using a chiral Ru-TsDPEN complex as the catalyst in DMF/MeOH at 40 °C. The reaction exhibits high reaction activity and excellent enantioselectivity where up to 96% yield and 99% ee of the product were obtained.
Z. Xu, Y. Li, J. Liu, N. Wu, K. Li, S. Zhu, R. Zhang and Y. Liu, Org. Biomol. Chem., 2015, 13, 7513 DOI: 10.1039/C5OB00568J
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